Itraconazole, Serum
Use
Itraconazole is a synthetic triazole antifungal drug used for treatment and prophylaxis of various fungal infections. Therapeutic drug monitoring of itraconazole is important due to concerns about adequate absorption and drug interactions. Ensuring systemic absorption is crucial for patients with life-threatening infections and those at risk for poor absorption or rapid clearance of the drug. Systemic infections generally require higher serum concentrations for efficacy.
Special Instructions
Timing of serum collection is recommended to be trough collections due to the drug's long half-life, but the timing is not as critical. Collect serum within 2 hours, centrifuge, and transfer to a plastic vial. Complete the Therapeutics Test Request form if not ordering electronically.
Limitations
Enteropathy, H2-histamine receptor blockers, and hepatic enzyme inducers may result in low serum levels, increasing the risk of therapeutic failure. Patients with AIDS or those receiving immunosuppressive therapy may require special consideration due to typically lower itraconazole levels.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
LOINC Codes
- 10989-2
- 10989-2
- 18337-6
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.18 mL
Container
Plastic vial
Collection Instructions
Collect serum within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.
Storage Instructions
Refrigerated (preferred), Ambient, or Frozen for up to 29 days.
Causes for Rejection
Gross hemolysis: OK, Gross lipemia: OK, Gross icterus: OK
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 29 days |
| Refrigerated | 29 days |
| Frozen | 29 days |