Jo 1 Antibodies, IgG, Serum
Use
The Jo 1 Antibodies, IgG, Serum test evaluates patients with clinical features of idiopathic inflammatory myositis, especially those suggestive of anti-synthetase syndrome or interstitial lung disease. Autoantibodies against aminoacyl-tRNA synthetases, including Jo-1, are key in identifying autoimmune conditions and aid in diagnosing myositis and defining its clinical subsets. This serves as a crucial diagnostic marker, given the association of these antibodies with syndromes like anti-synthetase syndrome and interstitial lung disease.
Special Instructions
For comprehensive instructions, refer to the Connective Tissue Disease Cascade document. If not ordering electronically, complete and send a Kidney Transplant Test Request form with the specimen.
Limitations
The performance characteristics of various assays for Jo 1 antibody detection are not extensively verified to establish comparability. A negative test does not rule out idiopathic inflammatory myositis. Results may vary based on the method and reagents used.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
LOINC Codes
- 33571-1
- 33571-1
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.35 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis, Gross lipemia, Heat-Treated
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 21 days |
| Frozen | 21 days |