Ki-67 (MIB-1) Immunostain, Technical Component Only
Use
Ki-67 (antibody clone MIB-1) is a nuclear protein playing a pivotal role in maintaining cell proliferation. Ki-67 is present in all non-G0 phases of the cell cycle. It is useful as a marker of proliferation and prognosis in various neoplasms, including malignant lymphomas, prostatic and breast adenocarcinomas, astrocytic neoplasms, and soft tissue neoplasms.
Special Instructions
This test includes only the technical performance of the stain; no pathologist interpretation is provided. Technical component only stains should not be ordered with Pathology Consultation (PATHC). If ordered with PATHC, the technical component stains will be canceled.
Limitations
This test does not include pathologist interpretation, only technical performance of the stain. The charge of glass slides can be affected by environmental factors, potentially altering slide staining. Staining consistency can be impacted by the age of cut paraffin sections, with stability being antigen dependent. Best practices include cutting paraffin sections within 6 weeks.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- Order only; no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Collection Instructions
Attach the green "Attention Pathology" address label (T498) and the pink Immunostain Technical Only label included in the kit to the outside of the transport container. Submit formalin-fixed, paraffin-embedded tissue block OR 2 unstained, positively charged glass slides (25- x 75- x 1-mm) per test ordered; sections 4-microns thick.
Causes for Rejection
Wet/frozen tissue, cytology smears, nonformalin fixed tissue, nonparaffin embedded tissue, noncharged slides, ProbeOn slides, Snowcoat slides