Leukocyte Adhesion Deficiency Type 1, CD11a/CD18 and CD11b/CD18 Complex Immunophenotyping, Blood
Use
Aiding in the diagnosis of leukocyte adhesion deficiency syndrome type 1, primarily in patients younger than 18 years. This test is useful for CD11a, CD11b, and CD18 phenotyping. Leukocyte adhesion deficiency syndrome type 1 is an autosomal recessive disorder caused by variants in the CD18 gene. It is characterized by recurrent infections, impaired wound healing, and persistent leukocytosis.
Special Instructions
Testing is not performed on Saturday, Sunday, or observed holidays. Only collect and ship specimens for arrival on days when testing is performed.
Limitations
This test is typically not indicated in adults. Expression of CD18 alone is insufficient to exclude the diagnosis of leukocyte adhesion deficiency syndrome type 1; functional assays like neutrophil chemotaxis may be necessary if clinical suspicion remains high.
New York Approved
Methodology
Cell-based / Cytometry (Flow Cytometry)
Biomarkers
LOINC Codes
- 94266-4
- 94268-0
- 94267-2
- 94265-6
- 69052-9
Result Turnaround Time
3-4 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
2 mL
Container
Lavender top (EDTA)
Collection Instructions
Send whole blood specimen in original tube. Do not aliquot. Collect and package specimen as close to shipping time as possible.
Causes for Rejection
Gross hemolysis, Gross lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |