Limited Bleeding Diathesis Profile Interpretation
Use
Interpretation of testing performed as part of a profile to detect the more common potential causes of abnormal bleeding, such as factor deficiencies/hemophilia, von Willebrand disease, and factor-specific inhibitors. It also provides a simple screen to evaluate for an inhibitor or severe deficiency of factor XIII, which is rare. This test serves as a useful diagnostic tool for clinicians to understand a patient's bleeding disorder profile.
Special Instructions
Test is not useful for assessing platelet function, such as congenital or acquired disorders like Glanzmann thrombasthenia, Bernard-Soulier syndrome, storage pool disease, and myeloproliferative disease, which require fresh platelets. The test is only orderable as part of a profile and not individually. It is essential to note if the patient is receiving anticoagulants such as warfarin or heparin as these can affect results. If recently transfused, it's advised to conduct the study pretransfusion if possible.
Limitations
The test does not directly assess platelet function, which requires fresh platelet samples. Patients on warfarin or heparin therapy may show altered coagulation factor levels, making some assays preclusive or resulting in spurious results. Accuracy may also be compromised if the patient has been recently transfused, hence prior transfusion should be noted in the results. The test also does not include alpha-2 plasmin inhibitor or plasminogen activator inhibitor as routine components.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 69049-5
- 18771-6
- 69049-5
Result Turnaround Time
7-21 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
Not provided
Minimum Volume
1 mL
Container
Citrate (Na Cit)
Causes for Rejection
Gross hemolysis, gross lipemia, gross icterus.
Stability Requirements
| Temperature | Period |
|---|---|
| Frozen | 14 days |