Liver Fatty Acid-Binding Protein (L-FABP) Immunostain, Technical Component Only
Use
Liver fatty acid-binding protein (L-FABP) is a cytoplasmic protein that binds free fatty acids and their coenzyme A derivative, bilirubin, and other hydrophobic ligands. It may have roles in lipid transport, uptake, and metabolism. L-FABP can be used with a panel of immunohistochemical markers (beta-catenin, glutamine synthetase, C-reactive protein, and amyloid A) to distinguish hepatic adenoma from focal nodular hyperplasia and non-neoplastic liver. L-FABP is downregulated in type 1 adenomas but is expressed in normal liver and other adenoma types.
Special Instructions
This test includes only technical performance of the stain; no pathologist interpretation is provided. Technical component only stains should not be ordered with PATHC / Pathology Consultation. If ordered with PATHC, the technical component stains will be canceled.
Limitations
The charge of glass slides can be affected by environmental factors and subsequently may alter slide staining. Sending unsuitable glass slides can result in inconsistent staining due to poor slide surface chemistry. Best practices for storage of positively charged slides include minimizing time after unpackaging and limiting exposure to high humidity and heat.
FDA ApprovedNew York Approved
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Collection Instructions
Formalin-fixed, paraffin-embedded tissue block OR 2 Unstained, positively charged glass slides (25- x 75- x 1-mm) per test ordered; sections 4-microns thick.
Storage Instructions
Ambient (preferred). Also acceptable refrigerated.
Causes for Rejection
Wet/frozen tissue, Cytology smears, Nonformalin fixed tissue, Nonparaffin embedded tissue, Noncharged slides, ProbeOn slides, Snowcoat slides.