Lorazepam (Ativan), Serum
Use
Lorazepam, commercially known as Ativan, is primarily used for its anxiolytic and sedative properties. Monitoring serum levels is critical for ensuring compliance with prescribed dosages, assessing the risk of side effects, and evaluating potential overdose or toxicity. The test is particularly useful for adjusting dosages in patients undergoing long-term therapy or those with altered drug clearance due to hepatic dysfunction, advanced age, or interacting medications. Accurate serum level assessment helps in personalizing treatment and avoiding complications such as sedation, confusion, and respiratory depression.
Special Instructions
The test requires prompt specimen handling and processing. Use only specified tubes for collection and ensure refrigeration if there are any transport delays. Do not use gel tubes for this test as they can interfere with accurate results. Coordinate with the testing laboratory for any specific submission requirements or queries related to test performance.
Limitations
The measurement of Lorazepam is subject to potential interference by substances such as other benzodiazepines. Ensure proper specimen handling to avoid degradation, and adhere to specified stability conditions for accurate results. Variability in results can occur due to differences in patient metabolism and potential non-compliance issues. The test may not detect all abnormalities associated with concomitant drug use and should be interpreted within the clinical context.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
LOINC Codes
- 59703-9
- 59703-9
Result Turnaround Time
5-13 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
2 mL
Minimum Volume
0.6 mL
Container
Green top; Plastic vial
Collection Instructions
Draw blood in a green-top sodium heparin tube(s), plasma gel tube is not acceptable. Centrifuge and send 2 mL of plasma refrigerated in a plastic vial.
Causes for Rejection
Plasma gel tube
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 14 days |
| Frozen | 180 days |