Lung Cancer, RET (10q11) Rearrangement, FISH, Tissue
Use
Identifying RET gene rearrangements in patients with late-stage, lung adenocarcinomas that are negative for epidermal growth factor receptor mutations and anaplastic lymphoma kinase rearrangements. It also supports the diagnosis of certain salivary gland, cutaneous, and other tumors when used in conjunction with an anatomic pathology consultation. Tumors with RET fusions may be sensitive to directed inhibitor therapy, suggesting potential response to targeted treatments.
Special Instructions
Not provided.
Limitations
This test is not approved by the U.S. Food and Drug Administration and is used as an adjunct to existing clinical and pathologic information. Fluorescence in situ hybridization (FISH) does not rule out other chromosomal abnormalities. Fixatives other than formalin may not be successful for FISH assays. Decalcified paraffin-embedded tissues have a lower success rate for FISH analysis. Insufficient cell counts or inadequate tissue may result in no analysis charges but may also impair result interpretation.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Unknown CNV
Copy Number Region
LOINC Codes
- 90927-5 - RET gene rearrange Bld/T FISH
- 50397-9 - Mol dx interp Bld/T Ql
- 69965-2 - Clinical cytogeneticist review
- 62356-1 - Chrom analy result (ISCN)
- 42349-1
- 31208-2 - Specimen source
- 80398-1 - Unique ID Current sample
- 85069-3 - Lab test method
- 18771-6 - Provider signing name
- 48767-8 - Annotation comment Imp
- 62364-5 - Test performance info Spec
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Formalin-fixed, paraffin-embedded tumor tissue block
Collection Instructions
Submit a formalin-fixed, paraffin-embedded tumor tissue block. Provide fixation method used.
Causes for Rejection
All specimens will be evaluated for test suitability.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |