Lyme Central Nervous System Infection IgG, Antibody Index, Spinal Fluid
Use
The test is used to provide antibody index information to aid in the diagnosis of neuroinvasive Lyme disease or neuroborreliosis due to Borrelia species associated with Lyme disease, such as Borrelia burgdorferi, Borrelia garinii, and Borrelia afzelli. The Lyme CNS antibody index quantitatively measures the level of anti-Borrelia antibodies in CSF and serum, which alongside clinical and exposure history can establish a diagnosis of neuroinvasive Lyme disease.
Special Instructions
Only orderable as part of a profile. CSF and serum must be collected within 24 hours of each other. Do not submit CSF from the first vial due to the possibility of blood contamination.
Limitations
False-negative results may occur if patients are tested soon after infection before antibody levels are detectable in CSF. False-reactive results may occur in patients with syphilis or Leptospira infections. The test should not be used to exclude the diagnosis without considering patient exposure history and clinical symptoms.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 92812-7
- 92811-9
- 69048-7
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
1.2 mL
Minimum Volume
Not provided
Container
Sterile vial
Collection Instructions
A spinal fluid (CSF) sample of 1.2 mL needs to be collected within 24 hours of the serum specimen, preferably at the same time. Label vial as spinal fluid or CSF.
Causes for Rejection
CSF contaminated with blood
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 11 days |
| Frozen | 35 days |