MAL Immunostain, Technical Component Only
Use
MAL is a nonglycosylated hydrophobic integral membrane protein that forms, stabilizes, and maintains glycosphingolipid-enriched membrane microdomains. MAL is known also as T lymphocyte maturation-associated protein. MAL expression is a specific marker of primary mediastinal large B-cell lymphoma. This test is useful for diagnosing primary mediastinal large B-cell lymphoma by detecting MAL expression through immunohistochemical staining.
Special Instructions
Not provided.
Limitations
This test does not include pathologist interpretation, only technical performance of the stain. The age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary widely among published literature and are antigen dependent. Best practice is for paraffin sections to be cut within 6 weeks. The charge of glass slides can be affected by environmental factors which may alter slide staining. Unsuitable glass slides can result in inconsistent staining due to poor slide surface chemistry.
FDA ApprovedNew York Approved
Methodology
Immunoassay (IHC)
Biomarkers
MAL
Protein
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Collection Instructions
Attach the green "Attention Pathology" address label (T498) and the pink Immunostain Technical Only label included in the kit to the outside of the transport container. Preferred specimen types include Formalin-fixed, paraffin-embedded tissue block or 2 Unstained, positively charged glass slides (25- x 75- x 1-mm) per test ordered; sections 4-microns thick.
Causes for Rejection
Wet/frozen tissue, Cytology smears, Nonformalin fixed tissue, Nonparaffin embedded tissue, Noncharged slides, ProbeOn slides, Snowcoat slides.