MAML2 (11q21) Rearrangement, Mucoepidermoid Carcinoma (MEC), FISH, Tissue
Use
This test is useful for identifying MAML2 rearrangements, which are detectable in 80% to 85% of mucoepidermoid carcinomas. It supports the diagnosis of mucoepidermoid carcinoma when used in conjunction with an anatomic pathology consultation. MAML2 rearrangements are not found in morphologic mimics but can be identified in other neoplasms such as hidradenoma, poroma, porocarcinoma, and hemangioendothelioma.
Special Instructions
Not provided.
Limitations
This test is not cleared or approved by the US Food and Drug Administration and is best used as an adjunct to existing clinical and pathologic information. The fluorescence in situ hybridization (FISH) assay does not rule out other chromosome abnormalities. Non-formalin fixed specimens may not succeed fully in FISH assays. Decalcified paraffin-embedded specimens have about a 50% success rate for FISH analysis. FISH studies require sufficient tumor tissue for analysis, and lack of sufficient tissue post-hybridization will result in a lack of FISH results.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 74034-0 - MAML2 11q21 Tiss FISH
- 50397-9 - Mol dx interp Bld/T Ql
- 69965-2 - Clinical cytogeneticist review
- 62356-1 - Chrom analy result (ISCN)
- 31208-2 - Specimen source
- 80398-1 - Unique ID Current sample
- 18771-6 - Provider signing name
- 42349-1
- 85069-3 - Lab test method
- 48767-8 - Annotation comment Imp
- 62364-5 - Test performance info Spec
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Submit a formalin-fixed, paraffin-embedded tumor tissue block. Blocks with alternative fixation methods like Prefer or Bouin's are less likely to succeed. Paraffin-embedded specimens can be from any anatomic location. Fresh tissue will be canceled upon receipt. If only fresh tissue is available, embed in paraffin before sending.
Causes for Rejection
Fresh tissue is rejected.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient |
| Refrigerated | Refrigerated |