Manganese/Creatinine Ratio, Random, Urine
Use
Monitoring manganese exposure using random urine specimens; nutritional monitoring; clinical trials. Manganese in urine represents excretion of excess body manganese and may be used to monitor exposure or excessive nutritional intake; useful in industrial exposure contexts, parenteral nutrition monitoring, and identifying potential neurotoxicity risks.
Special Instructions
Patient preparation: avoid specimen collection within 96 hours after gadolinium- or iodine-containing contrast media administration due to interference with ICP‑MS assays. Use Metal‑free urine collection procedures. Requires clean plastic container with no metal cap or glued insert; see Metals Analysis Specimen Collection and Transport for complete instructions.
Limitations
Contamination is always a possibility because environmental manganese levels are high and daily urinary excretion is low; proper metal‑free collection procedures are essential. Interpretation limited by lack of established reference ranges in individuals under 18 years; pediatric values not established.
New York Approved
Methodology
Mass Spectrometry (LC‑MS/MS)
Biomarkers
LOINC Codes
- 27367-2
- 2161-8
- 27367-2
Result Turnaround Time
2-8 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
3 mL
Minimum Volume
2 mL
Container
Clean, plastic urine collection container with no metal cap or glued insert; submission in plastic 10 mL urine tube or aliquot container with no metal cap or glued insert
Collection Instructions
Collect a random urine specimen; avoid collection within 96 hours of gadolinium‑ or iodine‑containing contrast; see Metals Analysis Specimen Collection and Transport
Patient Preparation
Avoid gadolinium‑ or iodine‑contrast media for 96 hours prior to collection
Storage Instructions
Refrigerated preferred; ambient or frozen acceptable per stability
Causes for Rejection
Specimens evaluated for suitability; metal contamination risk (not explicit rejection criteria)
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 28 days |
| Frozen | 28 days |