Manganese, Serum
Use
Manganese (Mn) is a trace essential element important for various industrial uses such as steel production, where it improves hardness, stiffness, and strength. It is naturally found in the environment and can be a major source of exposure via inhalation and ingestion, particularly in vegetarians or heavy tea drinkers with diets high in grains, beans, and nuts. Mn toxicity can cause serious symptoms affecting neurological function, progressing through stages of malaise, psychological disturbances, and motor function impairments. This test is useful for monitoring manganese exposure using serum specimens.
Special Instructions
Metal-free serum collection procedures are crucial to avoid contamination. Follow strict guidelines in specimen collection and handling. Specimens collected from healthy, unexposed adults should have low Mn levels, and elevated results may require careful consideration due to environmental contamination risks.
Limitations
High concentrations of gadolinium and iodine may interfere with ICP-MS based metal tests. Specimens should not be collected within 96 hours following contrast media administration. Potential for contamination necessitates the use of metal-free collection and handling. Results may be influenced by environmental exposure leading to contamination.
New York Approved
Methodology
Mass Spectrometry (ICP-MS)
Biomarkers
LOINC Codes
- 5683-8
- 5683-8
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1.6 mL
Minimum Volume
0.3 mL
Container
7-mL Mayo metal-free, screw-capped, polypropylene vial
Collection Instructions
Refer to Metals Analysis Specimen Collection and Transport instructions. Use 6 mL plain, royal blue-top Vacutainer plastic trace element blood collection tube.
Patient Preparation
Avoid collecting specimens for 96 hours post administration of gadolinium or iodine-containing contrast media.
Causes for Rejection
Gross hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 28 days |
| Refrigerated | 28 days |
| Frozen | 28 days |