Measles (Rubeola) Virus Antibody, IgM and IgG, Serum

Casandra

Casandra Test Code MC66090Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID ROGMCPT Code 86765

Measles (Rubeola) Virus Antibody, IgM and IgG, Serum

Clinical Use

Use

This test is useful for diagnosing measles virus infection and determining the immune status of individuals through IgG antibody testing. It also aids in documenting previous infection with the measles virus in individuals lacking a prior immunization record. The detection of IgM-class antibodies suggests recent infection, whereas IgG-class antibodies indicate prior exposure, either through infection or vaccination. Accurate diagnosis is critical due to the highly contagious nature of measles, which can spread through direct contact with aerosolized droplets or respiratory secretions from infected individuals.

Special Instructions

If not ordering electronically, complete, print, and send the Infectious Disease Serology Test Request form with the specimen. This information is important for ensuring proper test processing.

Limitations

The presence of IgM-class antibodies, with or without IgG-class antibodies, may support a diagnosis of recent infection but should not be used alone to diagnose measles virus infection. A serum specimen collected during the acute phase may yield negative results for IgM or IgG antibodies. IgG-class antibodies may be present in serum from individuals who have received blood products but have not been immunized or previously infected with measles. Rare heterotypic IgM responses have been reported with other infections like rubella and chronic active hepatitis.

Test Details

FDA Approved