Methadone Confirmation, Chain of Custody, Random, Urine
Use
Methadone Confirmation, Chain of Custody, Random, Urine test is essential for monitoring compliance with methadone treatment for analgesia or drug rehabilitation. It assesses compliance with rehabilitation programs. The test is significant in a legal context where chain of custody is required to ensure results can withstand court scrutiny. This test measures levels of methadone and its primary metabolite, EDDP, providing insights into the efficacy and adherence of methadone therapy.
Special Instructions
This test must be conducted under strict chain-of-custody protocols to ensure legal defensibility using a Chain of Custody Kit. The test measures both methadone and EDDP levels, crucial for accurate monitoring of therapeutic compliance and to prevent potential adulteration by specimen spiking.
Limitations
The concentration of methadone in urine does not correlate well with serum levels or administered dosage due to interindividual and intraindividual variability in metabolism and urine pH. Spiking of urine with methadone can lead to non-detection of EDDP, indicating adulteration. The test's reliability is dependent on adherence to collection and chain-of-custody procedures to avoid specimen tampering.
New York Approved
Methodology
Mass Spectrometry (GC-MS)
Biomarkers
LOINC Codes
- 104626-7
- 70149-0
- 104627-5
- 104628-3
- 69050-3
- 77202-0
Result Turnaround Time
3-7 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
10 mL
Minimum Volume
2.5 mL
Container
Chain-of-custody kit containing the specimen containers, seals, and documentation required.
Collection Instructions
Collect urine specimen in the container provided, seal, and submit with the associated documentation to satisfy the legal requirements for chain-of-custody testing.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 28 days |
| Frozen | 28 days |