Monoclonal Protein Isotype, Quantitative, Serum
Use
This test is used for aiding in the diagnosis and monitoring of monoclonal gammopathies, especially when used in conjunction with free light chain studies. Monoclonal proteins, or M-proteins, are markers for monoclonal gammopathies, which can include a range of diagnoses from multiple myeloma to monoclonal gammopathy of undetermined significance (MGUS). The Mayo Clinic MASSFIX method offers enhanced sensitivity in detecting M-proteins and can replace traditional methods for common M-protein isotypes like IgG, IgA, and IgM.
Special Instructions
Not provided.
Limitations
Quantitation of IgD, IgE, free kappa, and free lambda cannot be performed by this assay. Free light chain monoclonal proteins should be quantified using the Immunoglobulin Free Light Chains, Serum test. IgD and IgE require separate assays and are not covered by this test. Results are highly dependent on the proper processing and handling of specimens.
New York Approved
Methodology
Mass Spectrometry (MALDI-TOF)
Biomarkers
LOINC Codes
- 74773-3 - Imm hevylite Pnl SerPl
- 74862-4 - IgG Kappa SerPl-mCnc
- 74863-2 - IgG lamba SerPl-mCnc
- 74864-0 - IgA kappa SerPl-mCnc
- 74865-7 - IgA lamba SerPl-mCnc
- 74866-5 - IgM kappa SerPl-mCnc
- 74867-3 - IgM lambda SerPl-mCnc
- 104267-0 - Protein glycosylated SerPl Ql
- 94400-9 - M Protein SerPl Ql
- 69048-7 - Immunologist review
Result Turnaround Time
2-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
Not provided
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Specimens with gross hemolysis, lipemia, or icterus are acceptable.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 28 days |
| Frozen | 28 days |