Monoclonal Protein Quantitation, 24 Hour, Urine
Use
Monitoring patients with monoclonal gammopathies using 24‑hour urine collections. The test quantifies total protein and evaluates protein electrophoretic patterns to identify monoclonal immunoglobulin light chains (M‑spike), aiding in the diagnosis and management of conditions such as multiple myeloma, primary systemic amyloidosis, and light‑chain deposition disease.
Special Instructions
Not provided.
Limitations
Urine protein electrophoresis alone is not considered an adequate screening for monoclonal gammopathies—reflex Mass‑Fix is performed if a discrete band is identified. Reference values not established for patients younger than 18 years.
New York Approved
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
LOINC Codes
- 101665-8 - MPQU 24h Ur
- 6941-9 - Albumin 24h Ur Elph-mRate
- 2889-4 - Prot 24h Ur-mRate
- 13362-9 - Specimen collect Time Ur
- 6794-2 - Alpha1 Glob 24h Ur Elph-mRate
- 6795-9 - Alpha2 Glob 24h Ur Elph-mRate
- 94714-3 - B-Globulin 24h Ur Elph-mRate
- 94715-0 - Gamma glob 24h Ur Elph-mRate
- 44294-7 - Albumin/Glob 24h Ur Elph
- 42482-0 - M Protein 24h Ur Elph-mRate
- 32210-7 - Prot Pattern 24h Ur Elph-Imp
Result Turnaround Time
4-6 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
50 mL
Minimum Volume
30 mL
Container
Plastic, 60‑mL urine bottle
Collection Instructions
Collect urine for 24 hours and refrigerate during collection; aliquot between 30 mL and 50 mL into plastic 60‑mL urine bottle.
Storage Instructions
Refrigerate during collection; send refrigerated.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient ≤ 24 hours |
| Refrigerated | Refrigerated ≤ 14 days |
| Frozen | Frozen ≤ 5 days |