Monoclonal Protein Screen, 24 Hour, Urine
Use
Monitoring patients with monoclonal gammopathies; detection of urine monoclonal proteins (M‑proteins) including identification of immunoglobulin light chains as seen in conditions such as multiple myeloma, primary systemic amyloidosis, light‑chain deposition disease, monoclonal gammopathy of undetermined significance, and idiopathic Bence‑Jones proteinuria. Urine total protein concentration, electrophoretic patterns, and M‑protein isotype are reported. Protein fractions (albumin; alpha‑1, alpha‑2, beta, gamma globulins) are quantified, and an M‑protein “M‑spike” may be identified.
Special Instructions
Not provided.
Limitations
MASSFIX alone is not considered adequate screening; must reflex to electrophoresis if positive. Hemolysis, radiographic agents, or penicillin may produce interference or false patterns (e.g., penicillin splits albumin band). Monoclonal gammopathies rarely seen in patients under 30. Interpretation depends on proper collection (24‑hour duration, adequate volume). Total protein reference value established only for age 18+, fractions reported when present.
New York Approved
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
LOINC Codes
- SMPU
- 617117
- 617118
- VL92
- TP6
- TM24
- CONCU
Result Turnaround Time
4-6 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
50 mL
Minimum Volume
30 mL
Container
Plastic, 60‑mL urine bottle (T313)
Collection Instructions
Collect urine for 24 hours and refrigerate specimen during collection. Aliquot between 30 mL and 50 mL into a plastic, 60‑mL urine bottle.
Storage Instructions
Send refrigerated (preferred)
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 14 days |
| Frozen | 5 days |