Monoclonal Protein Studies, Random, Urine
Use
Used for identifying monoclonal gammopathies using random urine specimens through analysis of urine proteins such as monoclonal immunoglobulin light chains, which are characteristic of conditions such as multiple myeloma, primary systemic amyloidosis, and light-chain deposition disease. The test’s components include protein electrophoresis, protein/creatinine ratio, and when indicated, M‑protein mass‑fix analysis, providing both detection and semi‑quantitative evaluation of monoclonal proteins in urine. The presence of monoclonal light chains may have renal implications such as Fanconi syndrome or light-chain deposition disease and reflect systemic plasma cell disorders.
Special Instructions
Library includes forms and algorithms such as Amyloidosis: Laboratory Approach to Diagnosis and Multiple Myeloma: Laboratory Screening for guidance. If not ordering electronically, complete and send the Renal Diagnostics Test Request (T830). Shipping: refrigerate during collection and transport.
Limitations
Random urine specimens are sufficient for detection of monoclonal proteins but less reliable than 24‑hour specimens for quantitation and monitoring. The presence of monoclonal gammopathies is rare in patients younger than age 30. Specimens are subject to suitability evaluation and may be rejected. Interpretation may be confounded by improper collection or handling.
New York Approved
Methodology
Mass Spectrometry (MALDI-TOF MS)
Biomarkers
LOINC Codes
- 101909-0
- 6942-7
- 2888-6
- 2161-8
- 9734-5
- 38190-5
- 9744-4
- 9745-1
- 44293-9
- 40661-1
- 49299-1
Result Turnaround Time
4-6 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
50 mL (30 mL minimum)
Minimum Volume
30 mL
Container
Plastic, 60‑mL urine bottle
Collection Instructions
Collect random urine specimen; aliquot 30 mL–50 mL into plastic, 60‑mL urine bottle.
Causes for Rejection
Specimen suitability evaluated at Mayo Clinic Laboratories; may be rejected if not adequate.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 14 days |
| Frozen | 5 days |