Mumps Virus Antibody, IgM and IgG, Serum

Casandra

Casandra Test Code MC63432Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID MMPGMCPT Code 86735

Mumps Virus Antibody, IgM and IgG, Serum

Clinical Use

Use

Diagnosis of mumps virus infection. Determination of postimmunization immune response of individuals to the mumps vaccine. Documentation of previous infection with mumps virus in an individual with no previous record of immunization to mumps virus. The mumps virus is a member of the Paramyxoviridae family of viruses, which include parainfluenza virus serotypes 1-4, measles, respiratory syncytial virus, and metapneumovirus. Mumps is highly infectious among unvaccinated individuals and is typically transmitted through inhalation of infected respiratory droplets or secretions. Laboratory diagnosis of mumps is typically accomplished by detection of IgM- and IgG-class antibodies to the mumps virus.

Special Instructions

If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen. Testing for IgM-class antibodies to mumps virus should be limited to patients with a clinically compatible disease.

Limitations

All positive IgM results must be interpreted cautiously as some false-positive results or heterotypical responses of the IgM have been seen in the serum of pregnant women or in patients with an acute infection caused by other viruses such as cytomegalovirus, herpes simplex virus, measles, rubella, or parvovirus. Mumps virus shares antigenic relationships with other viruses of the paramyxovirus group; therefore, serologic cross-reactions are possible but uncommon with this test procedure. Serum specimens obtained during the acute phase of infection or soon after vaccination may be negative for IgM- or IgG-class antibodies.

Test Details

FDA Approved