MyoMarker 3 Profile
Use
The idiopathic inflammatory myopathies (IIM) are a heterogeneous group of disorders characterized by muscle weakness, resulting from chronic muscle inflammation of unknown cause. Patients with IIM have a variety of autoantibodies with various clinical utilities that fall into two main groups. One group of autoantibodies are found in patients with myositis and are known as Myositis Specific Autoantibodies (MSA). The MSAs are highly specific for patients with polymyositis (PM) dermatomyositis (DM), anti-synthetase syndrome and necrotizing myositis. The second group of autoantibodies are considered Myositis Associated Autoantibodies (MAA). These appear in myositis overlap syndrome and in other connective tissue diseases, which correlate with certain clinical and/or pathophysiological conditions.
Special Instructions
Not provided.
Limitations
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 35333-4 - ENA Jo1 Ab Ser IA-aCnc
- 33772-5 - PL7 Ab Ser Ql
- 33771-7 - PL12 Ab Ser Ql
- 45149-2 - Ej Ab Ser Ql
- 45152-6 - OJ Ab Ser Ql
- 33921-8 - SRP Ab SerPl Ql
- 18485-3 - MI2 Ab Ser Ql
- 88739-8 - TIF1-gamma Ab Ser Line blot-aCnc
- 88725-7 - MDA5 Ab Ser Line blot-aCnc
- 82425-0 - Mj Ab Ser Line blot-aCnc
- 31562-2 - ENA PM/SCL Ab Ser-aCnc
- 49963-2 - Fibrillarin Ab Ser Ql
- 68549-5 - U2 snRNP Ab Ser Ql
- 57662-9 - U1 snRNP Ab Ser IA-aCnc
- 18484-6 - Ku Ab Ser Ql
- 70257-1 - ENA SS-A 52kD IgG Ser IA-aCnc
Result Turnaround Time
16-25 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
5 mL
Minimum Volume
4 mL
Container
Plastic vial
Collection Instructions
Draw blood in a plain red-top tube(s), serum gel tube is acceptable. Separate serum from cells within 1 hour of collection and send 5 mL of serum refrigerated in a plastic vial.
Causes for Rejection
Gross hemolysis, gross lipemia, gross icterus, anything other than serum, bacterial contamination
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 60 days |