Nonalcoholic Steatohepatitis (NASH)-FibroTest, Serum and Plasma
Use
The NASH-FibroTest is useful for diagnosing and following up on liver fibrosis, steatosis, and inflammation. It helps estimate hepatic fibrosis and assess inflammation for metabolic diseases. The test is valuable for patients with nonalcoholic fatty liver disease and steatosis (NAFLD) as it assesses the severity of nonalcoholic steatohepatitis (NASH) and confirms cases of steatosis without fibrosis, benefiting patient management, especially those with severe liver conditions like advanced fibrosis and NASH.
Special Instructions
Not provided.
Limitations
The test interpretation has not been validated for liver transplant patients and may not be reliable in cases of acute hemolysis, hepatitis, or inflammation. It should be interpreted with caution in chronic hemolysis or Gilbert syndrome. In instances of extreme component value discrepancies or biopsy discordance, the advice of a specialist is recommended. The test encompasses a degree of variability, especially in fibrotic stages, due to biological fluctuations.
New York Approved
Methodology
Other (Algorithm)
Biomarkers
LOINC Codes
- 93691-4 - NASH + fibrosis Pnl SerPl
- 1975-2 - Bilirub SerPl-mCnc
- 1743-4 - ALT SerPl w P-5'-P-cCnc
- 1835-8 - A2 Macroglob SerPl-mCnc
- 1869-7 - Apo A-I SerPl-mCnc
- 2324-2 - GGT SerPl-cCnc
- 46127-7 - Haptoglob SerPl Neph-mCnc
- 1558-6 - Glucose p fast SerPl-mCnc
- 2571-8 - Trigl SerPl-mCnc
- 2093-3 - Cholest SerPl-mCnc
- 30239-8 - AST SerPl w P-5'-P-cCnc
- 48795-9 - Liver fibr score SerPl Calc.FibroSure
- 48794-2 - Fibrosis stage SerPl Ql
- 88447-8 - Liver fibrosis interpretation Ser-Imp
- 93692-2 - NASH score SerPl
- 93693-0 - NASH grade SerPl Ql
- 93694-8 - NASH interpretation SerPl-Imp
- 93695-5 - Liver steatosis score SerPl
- 93696-3 - Liver steatosis grade SerPl Ql
- 93697-1 - Liver steatosis interp SerPl-Imp
- 48767-8 - Annotation comment Imp
Result Turnaround Time
2-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
4 mL
Minimum Volume
2 mL
Container
Amber vial
Collection Instructions
Centrifuge and aliquot serum into an amber vial within 2 hours of collection. Serum must be light protected within 4 hours of collection.
Patient Preparation
Fasting: 12 hours, required
Storage Instructions
Refrigerated preferred. Ambient for 24 hours. Frozen for 14 days.
Causes for Rejection
Gross hemolysis, lipemia, icterus, and samples from patients under 14 years of age
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 7 days |
| Frozen | 14 days |