Oligoclonal Banding, Spinal Fluid
Use
The detection of increased intrathecal immunoglobulin (IgG) synthesis is the basis for diagnostic laboratory tests for multiple sclerosis (MS). This includes oligoclonal band detection. Abnormal CSF oligoclonal band patterns occur in approximately 70% to 80% of MS patients. However, increased intrathecal IgG synthesis can occur in other inflammatory cerebrospinal fluid (CSF) diseases, so results are not specific for MS and clinical correlation is recommended. This test is useful for the diagnosis of multiple sclerosis, particularly in patients with equivocal clinical or radiologic findings. ([mayocliniclabs.com](https://www.mayocliniclabs.com/test-catalog/overview/3484?utm_source=openai))
Special Instructions
This test is not orderable as a standalone; it is only orderable as part of a profile—specifically as part of "OLIG / Oligoclonal Banding, Serum and Spinal Fluid" or "MSP3 / Multiple Sclerosis (MS) Cascade, Serum and Spinal Fluid." ([mayocliniclabs.com](https://www.mayocliniclabs.com/test-catalog/overview/3484?utm_source=openai))
Limitations
Not explicitly detailed in the rendered content. Limitations mentioned include lack of specificity—other inflammatory, infectious, cerebrovascular, or paraneoplastic neurological disorders may also produce CSF-specific IgG synthesis and oligoclonal bands, requiring clinical correlation. ([mayocliniclabs.com](https://www.mayocliniclabs.com/test-catalog/overview/3484?utm_source=openai))
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
4-7 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
Not provided
Minimum Volume
Not provided