Oxcarbazepine Metabolite, Serum
Use
The Oxcarbazepine Metabolite, Serum test is useful for monitoring serum concentration during oxcarbazepine therapy. It helps assess patient compliance and potential toxicity associated with Oxcarbazepine usage. Oxcarbazepine serves as monotherapy and adjunctive therapy for partial seizures. It is metabolized to 10-hydroxy-10,11-dihydrocarbamazepine (MHC), which is the active metabolite responsible for the therapeutic effects of Oxcarbazepine. The test measures the concentration of this active metabolite in serum, which is crucial for adjusting dosage and avoiding toxicity.
Special Instructions
Not provided.
Limitations
This test cannot be performed on whole blood; only serum separated within 2 hours is acceptable. Specimen handling issues such as improper separation from cells, or using inappropriate containers, may lead to reject specifications. Toxic levels for Oxcarbazepine have not been well established, and some patients may exhibit effective therapeutic concentration ranges outside the typical therapeutic range of 10-35 mcg/mL.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
10-Hydroxy-10,11-Dihydrocarbamazepine
Analyte
LOINC Codes
- 31019-3 - 10OH-Carbazepine SerPl-mCnc
- 31019-3 - 10OH-Carbazepine SerPl-mCnc
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Plastic vial
Collection Instructions
Collect specimen immediately before next scheduled dose. Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis: OK, Gross lipemia: OK, Gross icterus: OK
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 28 days |
| Refrigerated | 28 days |
| Frozen | 28 days |