Pancreatic Polypeptide, Plasma
Use
Detecting pancreatic endocrine tumors and assessing vagal nerve function after meal or sham feeding. Pancreatic polypeptide (PP) is secreted by the pancreas in response to hypoglycemia, ingestion of food, or 'sham' feeding secondary to vagal nerve stimulation. Markedly elevated levels are often associated with endocrine tumors of the pancreas such as insulinoma, glucagonoma, pancreatic polypeptide-secreting tumor of the pancreas. Patients with diabetes may also have elevated PP levels.
Special Instructions
Not provided.
Limitations
Nonfasting state results in falsely elevated values. The sham feeding test is invalid if food is swallowed. This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held and assayed after the radioactivity has sufficiently decayed, resulting in a test delay.
New York Approved
Methodology
Immunoassay (RIA)
Biomarkers
Pancreatic Polypeptide
Protein
LOINC Codes
- 2721-9 - Panc Polypept SerPl-mCnc
- 2721-9 - Panc Polypept SerPl-mCnc
Result Turnaround Time
4-8 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
3 mL
Minimum Volume
0.35 mL
Container
Plastic vial
Collection Instructions
1. Place specimen on wet ice and keep cold at all times following collection. 2. Centrifuge (refrigerated centrifuge not required) and aliquot plasma into a plastic vial. Freeze immediately.
Patient Preparation
Fasting: 8 hours, required
Storage Instructions
Frozen (preferred) for 90 days, Ambient for 7 days, Refrigerated for 14 days
Causes for Rejection
Gross hemolysis, Gross lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 90 days |