Paraneoplastic Pemphigus Antibody, IgG, Serum
Use
Paraneoplastic pemphigus (PNP), also known as paraneoplastic autoimmune multiorgan syndrome (PAMS), is an autoimmune mucocutaneous blistering disease often indicating an underlying malignancy. It is associated with non-Hodgkin lymphoma, chronic lymphocytic leukemia, thymoma, or Castleman disease. This test aids in diagnosing PNP/PAMS in the presence of erosive or lichenoid mucocutaneous disease, supporting the diagnosis through the detection of associated autoantibodies.
Special Instructions
Not provided.
Limitations
The test may not fully exclude paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome as a diagnosis due to its lack of complete sensitivity. Negative results do not definitively rule out the syndrome, and positive results should be correlated with clinical presentation and additional laboratory studies.
New York Approved
Methodology
Immunoassay (Indirect Immunofluorescence Assay (IFA))
Biomarkers
LOINC Codes
- 93233-5 - ICS IgG Ser Ql IF
- 93233-5 - ICS IgG Ser Ql IF
Result Turnaround Time
7 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
0.5 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis, Gross lipemia, Gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 30 days |