Parietal Cell Antibodies, IgG, Serum
Use
This test is used for evaluating patients suspected of having pernicious anemia or autoimmune-mediated deficiency of vitamin B12. It helps in diagnosing pernicious anemia by detecting parietal cell antibodies, which are associated with autoimmune destruction of parietal cells in the stomach.
Special Instructions
Patients with a clinical suspicion of pernicious anemia but negative initial test results may need retesting in 4-6 weeks.
Limitations
The presence of immune complexes or other immunoglobulin aggregates may cause false-positive results due to increased nonspecific binding. A negative result does not rule out the presence of parietal cell antibodies, as the concentration may be below the detection limit. This test is not validated for matrices other than serum, and its performance characteristics for pediatric patients have not been established.
FDA ApprovedNew York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 40960-7
- 40960-7
Result Turnaround Time
2-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.4 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis, gross lipemia, or heat-treated specimens may be rejected. Gross icterus specimens are acceptable.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 21 days |
| Frozen | 21 days |