Use

Phosphofructokinase enzyme activity test is useful for the evaluation of individuals with Coombs-negative nonspherocytic hemolytic anemia and those with exercise intolerance or myopathy. It is also valuable for genetic studies in families with phosphofructokinase deficiency, which can manifest in several clinical subtypes, including classical, late-onset, infantile, and hemolytic forms. The measurement of red blood cell PFK activity helps identify compensated or mild hemolytic anemia and other symptoms like hyperuricemia or gout-like conditions.