Phosphorylated TDP43 Immunostain, Technical Component Only
Use
Identification of pathological forms of TDP-43 in neurodegenerative diseases. TDP-43 has functions in transcriptional repression, translational regulation, and pre-mRNA splicing. In normal cells, it is nuclear, while in affected cells, it is phosphorylated and found in inclusions and neurites, characteristic of amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Special Instructions
Not provided.
Limitations
This test does not include pathologist interpretation, only technical performance of the stain. The age of paraffin sections can affect immunoreactivity, with stability thresholds being variable. Unsuitable glass slides can result in inconsistent staining. Best practices include minimizing slide storage after unpackaging and limiting exposure to high humidity and heat.
FDA ApprovedNew York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Phosphorylated TDP-43
Protein
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Storage Instructions
Ambient (preferred) or Refrigerated
Causes for Rejection
Wet/frozen tissue, Cytology smears, Nonformalin fixed tissue, Nonparaffin embedded tissue, Noncharged slides, ProbeOn slides, Snowcoat slides