Primary Biliary Cholangitis Antibody Panel, Serum
Use
The Primary Biliary Cholangitis (PBC) Antibody Panel is used for the optimal diagnostic evaluation in at-risk patients for PBC. It aids in the early identification of patients at risk of PBC with or without incomplete features of the disease. Additionally, it is useful for the reevaluation of PBC patients exhibiting new features of other liver diseases or systemic autoimmune diseases. This test includes antibodies diagnostic for PBC, assists in confirming PBC diagnosis, predicts the development of the disease in preclinical cases, and helps in risk stratification and prognosis.
Special Instructions
Not provided.
Limitations
Serologic tests for autoantibodies, including anti-gp210 and anti-Sp100, should not be relied upon exclusively to determine the etiology or prognosis of PBC. Correlations between these antibodies for specific HEp-2 immunofluorescence assay patterns are variable. Negative results for anti-gp210 antibodies and/or anti-Sp100 antibodies do not exclude a PBC diagnosis. Positive results for antimitochondrial antibodies of M2 specificity are sometimes seen in those with systemic sclerosis or individuals without clinical evidence of systemic autoimmune rheumatic disease.
FDA ApprovedNew York Approved
Methodology
Immunoassay
Biomarkers
LOINC Codes
- 106054-0 - PBC comprehensive Ab pnl SerPl
- 51715-1 - Mitochondria M2 Ab Ser IA-aCnc
- 59069-5 - ANA Ser Ql HEp2 subst
- 33253-6 - ANA Titr Ser HEp2 subst
- 49311-4 - ANA Pat Ser IF-Imp
- 55171-3 - Cytoplasmic Ab pattern Ser IF-Imp
- 77202-0 - Laboratory comment Report
- 96565-7 - sp100 Ab Ser IA-aCnc
- 96560-8 - Nuclear pore prot gp210 Ab Ser IA-aCnc
Result Turnaround Time
2-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1.5 mL
Minimum Volume
1.1 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis, gross lipemia, heat-treated specimen
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 21 days |
| Frozen | 21 days |