Promethazine (Phenergan)
Use
Promethazine (Phenergan) is a medication primarily used to treat allergies, nausea, and vomiting. It is also used to provide sedation prior to surgery and to enhance the effects of certain opioid medications. The test measures the concentration of promethazine in plasma or serum to ensure therapeutic dosing and to monitor compliance, as well as to investigate potential overdose situations.
Special Instructions
Ensure proper specimen collection by drawing blood in either a green-top sodium heparin tube or a plain red-top tube. Avoid using plasma or serum gel tubes as they are not acceptable. The specimen should be spun down and sent refrigerated in a plastic vial.
Limitations
The test is limited to providing quantitative concentration data for promethazine only. It does not allow for the detection of its metabolites. Hemolysis, lipemia, icterus, and EDTA presence in the sample may cause rejection of the specimen. Variations in sample collection methods may affect results.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
LOINC Codes
- 3988-3
- 3988-3
Result Turnaround Time
7-11 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
3 mL
Minimum Volume
0.6 mL
Container
Plastic vial
Collection Instructions
Draw blood in a green-top (sodium heparin) tube, spin down, and send refrigerated.
Causes for Rejection
EDTA
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 14 days |
| Frozen | 180 days |