Proteinase 3 Antibodies, IgG, Serum
Use
Proteinase 3 antibodies, also known as PR3-ANCA, are associated with certain types of ANCA-associated vasculitis including granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). This test is useful in evaluating patients for these conditions, distinguishing between GPA and other forms of ANCA-associated vasculitis when used in conjunction with myeloperoxidase antibody and cytoplasmic neutrophil antibody testing, and monitoring treatment response in patients with proteinase 3 antibodies.
Special Instructions
Not provided.
Limitations
A positive result for proteinase 3 (PR3)-anti-neutrophil cytoplasmic antibodies (ANCA), myeloperoxidase (MPO)-ANCA, or ANCA by indirect immunofluorescence is not solely diagnostic for any ANCA-associated vasculitis and must be interpreted in the clinical context of the patient. Negative results for PR3-ANCA, MPO ANCA, and ANCA by IIF do not exclude the possibility of ANCA-associated vasculitis. Monitoring reactivity of PR3-ANCA or MPO-ANCA should not be relied upon solely to evaluate treatment response or assess the risk of disease flare.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Multiplex)
Biomarkers
Proteinase 3
Antibody
LOINC Codes
- 74106-6 - Proteinase3 IgG SerPl IA-aCnc
- 74106-6 - Proteinase3 IgG SerPl IA-aCnc
Result Turnaround Time
2-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.35 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis, Gross lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 21 days |
| Frozen | 21 days |