Q Fever IgM and IgG, Titer, Serum

Casandra

Casandra Test Code MC26705Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID QFPCPT Code 86638

Q Fever IgM and IgG, Titer, Serum

Clinical Use

Use

Q fever, a rickettsial infection caused by Coxiella burnetii, has been recognized as a widely distributed zoonosis with the potential for causing both sporadic and epidemic disease. This test is used for diagnosing Coxiella burnetii, the causative agent of Q fever. The resistance of C. burnetii to heat, chemical agents, and desiccation allows the agent to survive for extended periods outside the host. C. burnetii is spread by the inhalation of infected material, largely from dried sheep and goat reproductive material; the organism is also shed in feces, milk, nasal discharge, placental tissue, and amniotic fluid from ruminant animals. The clinical spectrum of disease ranges from unapparent to fatal. Respiratory manifestations usually predominate; endocarditis and hepatitis can be complications.

Special Instructions

Only orderable as a reflex test, meaning it cannot be ordered directly but must follow a Q Fever Antibody Screen with Titer Reflex, Serum. This indicates a workflow where the test may be performed as a follow-up based on initial screening results.

Limitations

Serologic responses are time-dependent. Specimens collected too early in the disease may not have detectable antibody levels, necessitating a second specimen collection 2 to 3 weeks later may be necessary to detect antibody. Low-level positive titers (i.e., <1:256) may remain for prolonged periods following resolution of disease, potentially leading to misinterpretation of active infection status.

Test Details

FDA Approved