Use

This test is useful for identifying defects in red blood cell enzyme metabolism and evaluating patients with Coombs-negative hemolytic anemia. Erythrocyte enzyme deficiencies are inherited causes of hemolytic anemia, with some being common, such as glucose 6-phosphate dehydrogenase (G6PD) deficiency, and others rare, affecting only a few families globally. Testing is crucial for a consultative evaluation to explore red cell enzyme activity as a cause of early red cell destruction.