Retinoblastoma Protein (Rb) Immunostain, Tech Only
Use
This test is useful for aiding in the identification of high-grade neuroendocrine carcinomas and small cell carcinomas. Retinoblastoma (Rb) is a phosphoprotein that acts as a tumor suppressor by providing a cell cycle checkpoint between G1 and S phases. Loss of nuclear expression of Rb can identify neuroendocrine carcinomas, small cell carcinomas, and can help differentiate spindle cell lipomas from myofibroblastomas and cellular angiofibromas from other genital stromal lesions.
Special Instructions
Not provided.
Limitations
This test does not include pathologist interpretation, only the technical performance of the stain. The age of a cut paraffin section can affect immunoreactivity and antigen stability, influenced by environmental conditions such as humidity and heat. Use fresh sections for optimal results and store glass slides properly to maintain staining integrity. Minimize exposure to environmental factors that can affect slide quality, such as humidity, heat, and plastics.
FDA ApprovedNew York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Retinoblastoma (Rb)
Protein
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Storage Instructions
Attach appropriate labels to transport containers to meet specific shipping instructions.
Causes for Rejection
Wet/frozen tissue, cytology smears, nonformalin fixed tissue, nonparaffin embedded tissue, noncharged slides, ProbeOn slides, Snowcoat slides
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |