Septin-7 Antibody, Tissue Immunofluorescence Titer, Serum
Use
The Septin-7 Antibody, Tissue Immunofluorescence Titer test is useful for detecting septin-7 IgG antibodies in serum specimens. This test is primarily used to report an end titer result from these specimens. The presence of septin-7 IgG is associated with neurological phenotypes such as encephalopathy, myelopathy, encephalomyelopathy, painful myelopolyradiculopathy, and episodic ataxia. These antibodies are also linked to psychiatric symptoms and cancer, and patients may respond positively to immunotherapy.
Special Instructions
Only orderable as a reflex test. Associated tests include ENS2 / Encephalopathy, Autoimmune/Paraneoplastic Evaluation, Serum; MDS2 / Movement Disorder, Autoimmune/Paraneoplastic Evaluation, Serum; MAS1 / Myelopathy, Autoimmune/Paraneoplastic Evaluation, Serum. If the indirect immunofluorescence pattern suggests septin-7 presence, additional testing will be performed at an extra charge.
Limitations
Negative results do not exclude neurological autoimmunity or cancer. Positive results by indirect immunofluorescence assay are consistent with autoimmune diseases of the central nervous system, but further testing by cell-binding assay for septin-7 IgG is required to confirm diagnosis. Interference by non-neuron-specific autoantibodies can usually be eliminated by serologic absorption.
New York Approved
Methodology
Immunoassay (Indirect Immunofluorescence Assay (IFA))
Biomarkers
LOINC Codes
- 101456-2
- 101456-2
Result Turnaround Time
5-10 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
See Specimen Required section for details.
Storage Instructions
Refrigerated for 28 days preferred, ambient for 72 hours, frozen for 28 days.
Causes for Rejection
Gross hemolysis, gross lipemia, gross icterus.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 28 days |
| Frozen | 28 days |