SOX10 Immunostain, Technical Component Only
Use
SOX10 (SRY-box transcription factor 10) is a nuclear transcription factor significant in schwannian and melanocytic cell differentiation. It is used as a marker in diagnosing melanocytic and schwannian tumors. SOX10 is expressed in benign melanocytic naevi, melanomas including desmoplastic and spindle cell melanomas, and schwannian-differentiated tumors like malignant peripheral nerve sheath tumors, Schwannomas, and neurofibromas. It is also expressed in normal tissues such as Schwann cells, melanocytes, and the myoepithelial cells of salivary, bronchial, and mammary glands.
Special Instructions
Not provided.
Limitations
The test does not include pathologist interpretation, only technical performance of the stain. Age and environmental conditions of glass slides can affect immunoreactivity. Controls should verify appropriate immunoreactivity. It is important that the test is interpreted in the context of the patient's clinical history by a qualified pathologist. Stability thresholds vary among publications and are antigen-dependent, with best practices recommending that paraffin sections be cut within 6 weeks prior to testing.
FDA ApprovedNew York Approved
Methodology
Immunoassay (IHC)
Biomarkers
SOX10
Protein
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Collection Instructions
Preferred specimen is a formalin-fixed, paraffin-embedded tissue block or two unstained, positively charged glass slides (25- x 75- x 1-mm) per test ordered, sections 4-microns thick.
Storage Instructions
Attach the green "Attention Pathology" address label and the pink Immunostain Technical Only label.
Causes for Rejection
Wet/frozen tissue, cytology smears, nonformalin fixed tissue, nonparaffin embedded tissue, noncharged slides, ProbeOn slides, Snowcoat slides.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |