SOX11 Immunostain, Technical Component Only
Use
SOX11 (SRY-box transcription factor 11) is a transcription factor involved in embryonic neurogenesis and tissue remodeling. Nuclear SOX11 is expressed in most B- and T-lymphoblastic leukemia/lymphomas and a proportion of Burkitt lymphomas, but only weakly expressed in some hairy cell leukemias. Mantle cell lymphomas show SOX11 expression and it has been suggested to correlate with overall survival. This test is useful for the identification of mantle cell lymphomas.
Special Instructions
Ordering this test includes only technical performance of the stain; no pathologist interpretation is provided. Technical component only stains should not be ordered with PATHC / Pathology Consultation. If ordered with PATHC, the technical component stains will be canceled. Shipping requires attaching the green "Attention Pathology" address label (T498) and the pink Immunostain Technical Only label to the transport container.
Limitations
The test does not include pathologist interpretation, only technical performance of the stain. Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist. The age of a cut paraffin section can affect immunoreactivity, and stability thresholds vary depending on the antigen. The quality of glass slides can affect staining results, with incorrect storage conditions potentially leading to inconsistent staining.
FDA ApprovedNew York Approved
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Collection Instructions
Formalin-fixed, paraffin-embedded tissue block OR 2 Unstained, positively charged glass slides (25- x 75- x 1-mm) per test ordered; sections 4-microns thick
Storage Instructions
Ambient (preferred), Refrigerated
Causes for Rejection
Wet/frozen tissue, Cytology smears, Nonformalin fixed tissue, Nonparaffin embedded tissue, Noncharged slides, ProbeOn slides, Snowcoat slides
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Until staining is complete. |