Supersaturation Profile, 24 Hour, Urine
Use
This test is useful for the diagnosis and management of patients with renal lithiasis. It helps in predicting the likely composition of the stone in patients who have a radiopaque stone but lack available stone analysis. The test can aid in designing a treatment program, identify specific risk factors for stones using a 24-hour urine collection, and monitor the effectiveness of therapy by confirming decreased crystallization potential. It evaluates kidney excretion of acid, urine pH, and estimates a patient's protein intake.
Special Instructions
Not provided.
Limitations
The test was developed and validated in compliance with CLIA requirements but has not been cleared or approved by the FDA. Improper specimen collection and handling, inappropriate test selection, and interfering substances can cause diagnostic confusion. Treatment may reduce the supersaturation with respect to one crystal type but increase supersaturation with another.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 81232-1 - Supersaturation Pnl 24h Ur
- 2162-6 - Creat 24h Ur-mRate
- 25308-8 - Ammonia 24h Ur-sRate
- 6874-2 - Calcium 24h Ur-mRate
- 6687-8 - Citrate 24h Ur-mRate
- 14862-7 - Oxalate 24h Ur-sRate
- 2701-1 - Oxalate 24h Ur-mRate
- 2079-2 - Chloride 24h Ur-sRate
- 8277-6 - BSA
- 3137-7 - Body height Measured
- 29463-7 - Weight
- 2829-0 - Potassium 24h Ur-sRate
- 24447-5 - Magnesium 24h Ur-mRate
- 2956-1 - Sodium 24h Ur-sRate
- 2694-8 - Osmolality 24h Ur
- 93746-6 - Protein catabolic rate 24h Ur-mRate
- 2779-7 - Phosphate 24h Ur-mRate
- 69051-1 - Urinalysis specialist review
- 81623-1 - CaOx 24h EngDiff Ur
- 101825-8 - Ca H2 Phos dihyd Cry 24h SatFr Ur
- 81622-3 - Hydroxyapatite 24h EngDiff Ur
- 101827-4 - Urate cry 24h SatFr Ur
- 13362-9 - Specimen collect Time Ur
- 3167-4 - Specimen vol 24h Ur
- 26889-6 - Sulfate 24h Ur-sRate
- 3096-5 - UUN 24h Ur-mRate
- 27378-9 - pH 24h Ur
- 3087-4 - Urate 24h Ur-mRate
Result Turnaround Time
2-5 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
35 mL
Minimum Volume
16 mL
Container
Plastic, 60-mL urine bottle
Collection Instructions
Add 5 mL of diazolidinyl urea as preservative at start of collection or refrigerate specimen during and after collection. Collect urine for 24 hours and ensure pH is between 4.5 and 8. Specimens with pH above 8 indicate bacterial contamination and testing will be canceled.
Patient Preparation
X-ray dyes and contrast media will affect uric acid results. If a kidney X-ray with dye or CT scan with contrast has been performed, wait a minimum of 1 day before starting collection. For cholangiography, wait 7 days before collection.
Storage Instructions
Refrigerated is preferred for up to 14 days, ambient for up to 72 hours, or frozen for up to 14 days.
Causes for Rejection
Specimens with pH above 8 indicate bacterial contamination and testing will be canceled. Do not attempt to adjust pH.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 14 days |
| Frozen | 14 days |