T-Cell Intracellular Antigen 1 (TIA-1) Immunostain, Technical Component Only
Use
TIA-1 is a protein that shows granular cytoplasmic staining patterns in cytotoxic granules. It is primarily found in cytotoxic T cells and is useful for characterizing neoplasms of cytotoxic T cells or NK cells. The test is used for identifying these neoplasms in patient samples, facilitating further diagnostic and treatment decisions.
Special Instructions
This test only performs the technical stain of TIA-1 without providing pathologist interpretation. For interpretative results, a pathology consultation (PATHC) should be ordered. Technical stains ordered with PATHC will be canceled.
Limitations
The test does not include a pathologist interpretation. The stability of cut paraffin sections affects the immunoreactivity of the stain, which may weaken over time. Environmental conditions can also affect the slide surface chemistry, which may lead to inconsistent staining results.
FDA ApprovedNew York Approved
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Collection Instructions
Formalin-fixed, paraffin-embedded tissue block or 2 unstained, positively charged glass slides (each 4 microns thick) per test ordered.
Storage Instructions
Minimize time slides are stored after unpackaging; limit exposure to high humidity and heat.
Causes for Rejection
Wet/frozen tissue, Cytology smears, Nonformalin fixed tissue, Nonparaffin embedded tissue, Noncharged slides.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |
| Refrigerated | Acceptable |