T-Cell Lymphoma, FISH, Tissue
Use
This test is useful for detecting recurrent common chromosome abnormalities in various T-cell lymphomas at diagnosis. It provides prognostic information for patients with documented systemic ALK-negative anaplastic large cell lymphoma. The test is used to evaluate paraffin-embedded tissue specimens, employing different probe sets according to the suspected lymphoma subtype, the patient's age, and clinical questions. The test aids in diagnosing T-cell lymphomas and contributes to determining the subtype and prognosis based on chromosome abnormalities detected.
Special Instructions
This test includes charges for probe application, analysis, and professional interpretation of results for one probe set. Additional charges apply for any reflex or additional probe sets performed. If a pathology consultation is desired, it should be ordered separately using PATHC. Mayo Hematopathology Consultants are involved in pre-analytic and post-analytic processes. Ensure that a complete pathology report accompanies the specimen, including patient details and reason for testing.
Limitations
The assay detects chromosome abnormalities in paraffin-embedded tissue samples; it will be canceled if non-paraffin embedded bone marrow or blood samples are received. Alternative fixation methods may be less favorable for successful results. Non-formalin-fixed tissues aren't rejected, but reliability decreases. Paraffin-embedded tissues that have been decalcified have about a 50% success rate in FISH analysis. Lack of sufficient representative cells prevents analysis, incurring no analysis charges. The absence of detected abnormalities doesn't rule out a neoplastic disorder or affect the pathological diagnosis.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 101682-3
- 50397-9
- 69965-2
- 93356-4
- 62356-1
- 42349-1
- 31208-2
- 80398-1
- 85069-3
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Formalin-fixed, paraffin-embedded tumor tissue block
Collection Instructions
Submit a tissue block prepared with formalin fixation. Provide the fixation method used. Include 1 hematoxylin and eosin-stained slide and 2 unstained slides for each probe set.
Storage Instructions
Ambient preferred, or refrigerated