Thrombin‑Antithrombin Complex
Use
Measurement of the thrombin‑antithrombin complex (TAT) provides insight into thrombin generation and coagulation activation. Elevated TAT levels may indicate hypercoagulable states, thrombotic events, inflammation, or microvascular thrombosis, assisting in diagnostic evaluation and clinical management in relevant patients.
Special Instructions
Collect blood in a 3.2% sodium citrate (light‑blue top) tube; mix gently by inversion at least six times. Centrifuge promptly, aliquot plasma into a plastic vial without disturbing cells, freeze immediately, and send frozen. Separate specimens are required when multiple tests are ordered.
Limitations
Pre‑analytical factors such as traumatic venipuncture, prolonged stasis, or improper mixing of anticoagulant may invalidate results. Prolonged stasis or inadequate centrifugation can cause falsely elevated values. TAT may be elevated non‑specifically in inflammation or surgical stress, potentially complicating interpretation.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 14182-0
- 14182-0
Result Turnaround Time
4-13 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
2 mL Plasma
Minimum Volume
1 mL
Container
Light‑blue top (3.2% sodium citrate) tube; plastic vial for submission
Collection Instructions
Mix blood gently by inversion at least six times; centrifuge, aliquot plasma carefully without disturbing cells, freeze immediately, send frozen.
Causes for Rejection
All specimens are evaluated for suitability; pre‑analytical conditions may invalidate results.
Stability Requirements
| Temperature | Period |
|---|---|
| Frozen | 180 days |