Thrombospondin Type 1 Domain Containing 7A (THSD7A), Immunofluorescence
Use
Thrombospondin type 1 domain-containing 7A (THSD7A) is a target antigen in membranous nephropathy (MN) and is detected in approximately 3% to 5% of non-phospholipase A2 receptor (PLA2R)-associated MN patients. Differentiating THSD7A-associated MN from PLA2R-associated MN is important as approximately 20% of patients with THSD7A-associated MN have solid malignancies, suggesting that THSD7A-associated MN is more likely to be secondary to malignancy than PLA2R-associated MN.
Special Instructions
Not provided.
Limitations
No significant cautionary statements are provided. Improper specimen collection, handling, and inappropriate test selection may cause diagnostic confusion. The laboratory will evaluate all specimens for test suitability.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
THSD7A
Protein
LOINC Codes
- 101116-2 - THSD7A Ag Tiss Ql IF
- 50595-8 - Path Interp Spec-Imp
- 19139-5 - Pathologist name
- 35265-8 - Path Report.addendum Spec
- 22634-0 - Path report.gross Spec
- 22633-2 - Path report.site of origin Spec
- 62364-5 - Test performance info Spec
- 80398-1 - Unique ID Current sample
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
2 Unstained positively charged glass slides (25- x 75- x 1-mm)
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |