Thyroid Transcription Factor (SPT24) Immunostain, Technical Component Only
Use
Thyroid transcription factor 1 (TTF1) is a nuclear protein expressed in thyroid follicular cells, type II pneumocytes, and a subset of bronchial cells. It is used to identify the primary site for carcinomas of unknown origin by specifically marking cells of thyroid or lung origin. This test is particularly useful in a panel of immunostains for identifying the primary site of carcinomas that originate from the thyroid or lung.
Special Instructions
Not provided.
Limitations
This test does not include pathologist interpretation, only technical performance of the stain. The interpretation should be done within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist. The age of a cut paraffin section can affect immunoreactivity, and stability thresholds can vary widely among published literature.
FDA ApprovedNew York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Thyroid transcription factor 1 (TTF1)
Protein
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostains Technical Only Envelope
Collection Instructions
Preferred: 2 Unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4-microns thick. Acceptable: Formalin-fixed, paraffin-embedded tissue block.
Causes for Rejection
Wet/frozen tissue, cytology smears, nonformalin fixed tissue, nonparaffin embedded tissue, noncharged slides, ProbeOn slides.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |
| Refrigerated | Refrigerated |