Tissue Transglutaminase Antibody, IgA, Serum
Use
The Tissue Transglutaminase Antibody, IgA, Serum test is primarily used to evaluate patients suspected of having celiac disease. It is particularly useful for those with compatible clinical symptoms as well as those with atypical symptoms. Individuals with a family history of celiac disease or those who are positive for HLA DQ2 and/or DQ8 are also candidates for this test. Additionally, it is used for screening for dermatitis herpetiformis in conjunction with the endomysial antibody test. This test aids in monitoring the response to a gluten-free diet in patients with dermatitis herpetiformis and celiac disease.
Special Instructions
Not provided.
Limitations
While this test is valuable, it should not be solely relied upon to establish a diagnosis of celiac disease. It identifies patients with a higher probability of having the disease, recommending a small intestinal biopsy for confirmation. Negative results may occur in individuals on a gluten-free diet. Further tests may be needed if the individual is IgA deficient or if clinical doubts persist.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
Tissue Transglutaminase
Protein
LOINC Codes
- 46128-5 - tTG IgA Ser IA-aCnc
- 46128-5 - tTG IgA Ser IA-aCnc
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.4 mL
Container
Serum gel or red top tube, aliquot into a plastic vial
Collection Instructions
Centrifuge and aliquot serum into plastic vial.
Storage Instructions
Refrigerated (preferred), stable for 21 days; Frozen, stable for 21 days
Causes for Rejection
Reject: Gross hemolysis, Gross lipemia; OK: Gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 21 days |
| Frozen | 21 days |