Tissue Transglutaminase Antibody, IgG, Serum
Use
This test is useful for individuals with IgA deficiency, evaluating patients suspected of having celiac disease (including those with compatible clinical symptoms, atypical symptoms, or an increased risk due to family history, previous diagnosis with associated disorder, or positivity for HLA DQ2 and/or DQ8), screening for dermatitis herpetiformis in conjunction with an endomysial antibody test, and monitoring response to a gluten-free diet in patients with dermatitis herpetiformis and celiac disease.
Special Instructions
Not provided.
Limitations
This test should not solely establish the diagnosis of celiac disease. It is primarily useful for identifying patients with an increased probability, in whom an intestinal biopsy may be warranted. Negative results could necessitate further investigation with endoscopy and biopsy, especially for patients with malabsorptive symptoms. Testing should be performed while the patient is on a gluten-containing diet.
FDA ApprovedNew York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 56537-4 - tTG IgG Ser IA-aCnc
- 56537-4 - tTG IgG Ser IA-aCnc
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.4 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis, Gross lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 21 days |
| Frozen | 21 days |