Ubiquitin (UBIQ) Immunostain, Technical Component Only
Use
The test is useful for the classification of neurodegenerative diseases. Ubiquitin is a polypeptide found in filamentous inclusions and cytosome-related organelles in idiopathic neurodegenerative diseases such as Alzheimer disease, Pick disease, Lewy body dementia, and Parkinson disease. It is also expressed in Rosenthal fibers in astrocytomas and in primary lysosome-related granules in mature neutrophils. Ubiquitin labels the periphery of senile plaques and neurofibrillary tangles in Alzheimer disease, Lewy bodies in Parkinson disease, and Mallory bodies in alcoholic liver disease.
Special Instructions
Not provided.
Limitations
The test does not include pathologist interpretation, only technical stain performance. Interpretation must be performed by a qualified pathologist in the context of the patient's clinical history and other diagnostic tests. Stability thresholds for paraffin sections vary and can affect immunoreactivity, with best practices recommending sections cut within 6 weeks. The charge of glass slides can be altered by environmental factors, resulting in inconsistent staining if unsuitable slides are sent.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Ubiquitin
Protein
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Collection Instructions
Formalin-fixed, paraffin-embedded tissue block or 2 unstained, positively charged glass slides (25- x 75- x 1-mm) per test. Sections should be 4-microns thick.
Causes for Rejection
Wet/frozen tissue, cytology smears, nonformalin fixed tissue, nonparaffin embedded tissue, noncharged slides, ProbeOn slides Snowcoat slides
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |