Vasoactive Intestine Polypeptide (VIP), Technical Component Only
Use
The test is useful for aiding in the identification of islet cell tumors. Excessive production of vasoactive intestine polypeptide (VIP) by islet cell tumors can be associated with Verner-Morrison syndrome (pancreatic cholera), characterized by massive, watery diarrhea. A subset of normal cells in the pancreatic islets express VIP (<1%). Peripheral nerves and ganglion cells also serve as a positive internal control.
Special Instructions
Not provided.
Limitations
This test does not include pathologist interpretation, only the technical performance of the stain. If interpretation is required, order PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion. Age of a cut paraffin section can affect immunoreactivity, with stability thresholds varying among published literature and antigen-dependent. Positively charged slides can be affected by environmental factors, affecting staining consistency. Best practices include minimizing storage time and limiting exposure to high humidity and heat.
FDA ApprovedNew York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Vasoactive Intestine Polypeptide
Protein
LOINC Codes
- Order only
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Collection Instructions
Attach the green 'Attention Pathology' address label (T498) and the pink Immunostain Technical Only label to the transport container.
Storage Instructions
Best practices for storage of positively charged slides include minimizing time stored after unpackaging, limiting exposure to high humidity and heat, and minimizing exposure to plastics.
Causes for Rejection
Wet/frozen tissue, cytology smears, nonformalin fixed tissue, nonparaffin embedded tissue, noncharged slides, ProbeOn slides, Snowcoat slides
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |