Yes-Associated Protein (YAP) Immunostain, Technical Component Only
Use
The Yes-associated protein (YAP) is a downstream regulatory target in the Hippo signaling pathway, upregulated in certain medulloblastomas associated with sonic hedgehog (SHH) and Wnt signaling pathways. YAP expression is found in various tissues, including the lung, placenta, prostate, ovary, and testis. This immunohistochemistry test helps in the identification and differentiation of medulloblastomas by staining tissue samples to evaluate YAP protein presence, assisting pathologists in tumor classification and further clinical decision-making.
Special Instructions
Not provided.
Limitations
The age of a cut paraffin section can impact immunoreactivity, and various factors like slide storage conditions can affect staining quality. It's important to minimize the time slides are stored once unpackaged, limiting exposure to humidity, heat, and plastics to ensure optimal slide conditions and prevent inconsistent staining results. This test is susceptible to variations in antigen stability across different paraffin-embedded tissue types, impacting the results' accuracy.
FDA ApprovedNew York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Yes-Associated Protein (YAP)
Protein
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Causes for Rejection
Wet/frozen tissue, Cytology smears, Nonformalin fixed tissue, Nonparaffin embedded tissue, Noncharged slides, ProbeOn slides, Snowcoat slides