Zinc, 24 Hour, Urine
Use
Identifying the cause of abnormal serum zinc concentrations using 24-hour urine specimens. Zinc is an essential element and a cofactor in multiple physiologically important proteins; elevated urinary zinc can reflect supplementation intake and help interpret abnormal serum levels. Useful for clinical situations involving zinc depletion or excess.
Special Instructions
Necessary information: 24‑Hour volume (in milliliters) is required. The method is triple‑quadrupole inductively coupled plasma mass spectrometry (ICP‑MS/MS). If barium‑containing contrast media has been administered, specimen collection should be delayed at least 96 hours. Urine preservative options include ambient (no additive) OK, refrigerated preferred, frozen OK; 50% acetic acid OK; boric acid, diazolidinyl urea, sodium carbonate, thymol, toluene are not acceptable. Provides links to Metals Analysis Specimen Collection and Transport and Urine Preservatives‑Collection and Transportation for 24‑Hour Urine Specimens.
Limitations
High concentrations of barium interfere—do not collect for at least 96 hours after administration. All specimens are evaluated for test suitability; inadequate volume or improper container types may lead to rejection.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
LOINC Codes
- 5765-3
- 5765-3
- 13362-9
- 3167-4
Result Turnaround Time
2-5 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
10 mL
Minimum Volume
0.4 mL
Container
Clean, plastic urine collection container with no metal cap or glued insert; submission in plastic urine tube or clean plastic aliquot container with no metal cap or glued insert
Collection Instructions
Collect urine for 24 hours; refrigerate specimen within 4 hours of completion of 24‑hour collection.
Patient Preparation
If barium‑containing contrast media has been administered, the specimen should not be collected for at least 96 hours.
Causes for Rejection
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 28 days |
| Refrigerated | 28 days |
| Frozen | 28 days |